Project: Understanding and Manipulating Cellular and Circuit-Level Vulnerability to Neurodegeneration in Parkinson’s disease
Aim: This project will study the brain cortex to assess the effects of Parkinson’s disease pathology progression on circuit function and identify vulnerable neuronal populations. See here for the collaborators in our team and the ASAP collaborative research network.
Grant details: ASAP-020616 (Biederer, T., coordinating lead PI) | Duration: Nov 1, 2021 – Oct 31, 2024

Project: Supporting Human Neuronal Connectivity through Bioactive Compounds
Duration: June 22, 2021 – September 21, 2024

Project: Dynamic Control of Synapse Organization and Function by Cleft-Resident Molecules
Aim: The project goals are to determine how the pre- and post-synaptic properties and plasticity-dependent remodeling of mature synapses are acutely instructed by cleft proteins. The application received a 1.0 percentile score.
Grant details: 1R01 MH119826 | Duration: March 6, 2019 – December 31, 2023

Project: Spread of alpha-Synuclein in the Pathology of Parkinson’s Disease
Aim: This project aims to identify and analyze cellular mechanisms that mediate the spread of alpha-synuclein fibrils
Grant details: R21 NS109637 | Duration: Feb 15, 2019 – Jan 31, 2022

Project: Mechanisms of SynCAM-Induced Synapse Formation
Aim: The goals of this project are to define synaptogenic signaling pathways and SynCAM activity in vivo
Grant details: R01 DA018928 | Duration: Mar 01, 2017 – Nov 30, 2021

Project: Identifying Synapse-Organizing Mechanisms through Proteomic Analyses of Mouse Models
Aim: This grant supports analyses of the synaptic proteome to delineate synapse development
Grant Details: P30 DA018343 | Duration: Jul 01, 2020 – May 31, 2025