Publications

Selected Research Articles

The human milk component myo-inositol promotes neuronal connectivity

Paquette, A., Carbone, B.E., Vogel, S., Israel., E., Maria, S.D., Patil, N., Sah, S., Chowdhury, D., Labhart, B., Morrow, A.L., Phillips, S.C., Kuang, C., Hondmann, D., Pandey, N., and Biederer, T. Proceedings of the National Academy of Sciences 120: e2221413120. July 2023, doi.org/10.1073/pnas.2221413120. Read PDF »

Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions

Perez de Arce, K., Ribic, A., Chowdhury, D., Watters, K., Thompson, G.J., Sanganahalli, B.G., Lippard, E., Rohlmann, A., Strittmatter, S.M., Missler, M., Hyder, F., and Biederer, T. Nature Communications. Jan 2023, doi.org/10.1038/s41467-023-36042-w. Read PDF »

LRRTM2 maintains synaptic strength through the subsynaptic positioning of AMPARs

Ramsey, A.M., Tang, A.-H., LeGates, T.A., Guo, X.-Z., Carbone, B.E., Thompson, S.M., Biederer, T. and Blanpied, T.A. Science Advances. Aug 2021, 7: doi.org/10.1126/sciadv.abf3126. Read PDF »

Synaptic connectivity and cortical function are promoted by the ω-3 fatty acid docosahexaenoic acid

Carbone, B. E., Abouleish, M., Watters, K., Vogel, S., Ribic, A., Bader, B. M., Schröder, Olaf H.-U., Xiao, Y., Kuang, C., and Biederer, T. Cerebral Cortex. Apr 2019, doi: 10.1093/cercor/bhz083. Read PDF »

Featured on Cover

Synapse-specific control of thalamocortical circuit maturation and cortical plasticity by the synaptic cell adhesion molecule SynCAM 1

Ribic, A., Crair, M.C., and Biederer, T. Cell Reports. Jan 2019, 26(2), 381-393, doi.org/10.1016/j.celrep.2018.12.069. Read PDF »

Mapping the proteome of the synaptic cleft through proximity labeling reveals new cleft proteins

Cijsouw, T., Ramsey, A.M., Lam, T.T., Carbone, B.E., Blanpied, T.A., and Biederer, T. Proteomes. Nov 2018, 6(4), 48, doi:10.3390/proteomes6040048. Read PDF »

Structural analyses of FERM domain-mediated membrane localization of FARP1

Kuo, Y.-C., He, X., Coleman, A., Chen, Y.-J., Dasari, P., Liou, J., Biederer, T., and Zhang, X. Scientific Reports. July 2018, 8:10477, doi: 10.1038/s41598-018-28692-4. Read PDF »

Reduced insulin/insulin-like growth factor receptor signaling mitigates defective dendrite morphogenesis in mutants of the ER stress sensor IRE-1

Salzberg, Y., Coleman, A., Celestrin, K., Cohen-Berkmann., M. Biederer, T., Henis-Korenblit, S., Bülow, H.E. PLoS Genetics. Jan 2017, 13:e1006579, doi: 10.1371/journal.pgen.1006579. Read PDF »

Excitatory synaptic drive and feedforward inhibition in the hippocampal CA3 circuit are regulated by SynCAM 1

Park KA, Ribic A, Laage Gaupp FM, Coman D, Huang Y, Dulla CG, Hyder F and Biederer T. Journal of Neuroscience. Jul 2016, 36:7464-75, doi: 10.1523/JNEUROSCI.0189-16.2016. Read PDF »

Topographic mapping of the synaptic cleft into adhesive nanodomains

Perez de Arce K, Schrod N, Metzbower SW, Allgeyer E, Kong GK, Tang AH, Krupp AJ, Stein V, Liu X, Bewersdorf J, Blanpied TA, Lucić V and Biederer T. Neuron. Dec 2015, 88:1165-72, doi: 10.1016/j.neuron.2015.11.011. Read PDF »

Faculty of 1000

Activity-dependent regulation of dendritic complexity by semaphorin 3A through Farp1

Cheadle L and Biederer T. Journal of Neuroscience. Jun 2014, 34:7999-8009, doi: 10.1523/JNEUROSCI.3950-13.2014. Read PDF »

Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1

Ribic A, Liu X, Crair MC and Biederer T. Journal of Comparative Neurology. Mar 2014, 522:900-20, doi: 10.1002/cne.23452. Read PDF »

The synaptic adhesion molecule SynCAM 1 contributes to cocaine effects on synapse structure and psychostimulant behavior

Giza JI, Jung Y, Jeffrey RA, Neugebauer NM, Picciotto MR and Biederer T. Neuropsychopharmacology. Mar 2013, 38:628-38, doi: 10.1038/npp.2012.226. Read PDF »

The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization

Cheadle L and Biederer T. Journal of Cell Biology. Dec 2012, 199:985-1001, doi: 10.1083/jcb.201205041. Read PDF »

Faculty of 1000 Featured on Cover

Lateral assembly of the immunoglobulin protein SynCAM 1 controls its adhesive function and instructs synapse formation

Fogel AI, Stagi M, Perez de Arce K and Biederer T. EMBO Journal. Sep 2011, 30:4728-38, doi: 10.1038/emboj.2011.336. Read PDF »

SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning

Robbins EM, Krupp AJ, Perez de Arce K, Ghosh AK, Fogel AI, Boucard A, Südhof TC, Stein V and Biederer T. Neuron. Dec 2010, 68:894-906, doi: 10.1016/j.neuron.2010.11.003. Read PDF »

N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion

Fogel AI, Li Y, Giza J, Wang Q, Lam TT, Modis Y and Biederer T. Journal of Biological Chemistry. Nov 2010, 285:34864-74, doi: 10.1074/jbc.M110.120865. Read PDF »

Featured on Cover

SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones

Stagi M, Fogel AI and Biederer T. Proceedings of the National Academy of Sciences USA. Apr 2010, 107:7568-73, doi: 10.1073/pnas.0911798107. Read PDF »

Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functions

Thomas LA, Akins MR and Biederer T. Journal of Comparative Neurology. Sep 2008, 510:47-67, doi: 10.1002/cne.21773. Read PDF »

SynCAMs organize synapses through heterophilic adhesion

Fogel AI, Akins MR, Krupp AJ, Stagi M, Stein V and Biederer T. Journal of Neuroscience. Nov 2007, 27:12516-30, doi: 10.1523/jneurosci.2739-07.2007. Read PDF »

Mixed-culture assays for analyzing neuronal synapse formation

Biederer T and Scheiffele P. Nature Protocols. Mar 2007, 2:670-6, 10.1038/nprot.2007.92. Read PDF »

SynCAM, a synaptic adhesion molecule that drives synapse assembly

Biederer T *, Sara Y, Mozhayeva M, Atasoy D, Liu X, Kavalali ET and Südhof TC *. Science. Aug 2002, 297:1525-31, doi: 10.1126/science.1072356. (*) co-corresponding authors. Read PDF »

Faculty of 1000

CASK and protein 4.1 support F-actin nucleation on neurexins

Biederer T * and Südhof TC. Journal of Biological Chemistry. Dec 2001, 276:47869-76. doi:10.1074/jbc.M105287200. (*) corresponding author. Read PDF »

Mints as adaptors. Direct binding to neurexins and recruitment of munc18

Biederer T * and Südhof TC *. Journal of Biological Chemistry. Dec 2000, 275:39803-6, doi: 10.1074/jbc.C000656200. (*) co-corresponding authors. Read PDF »

Role of Cue1p in ubiquitination and degradation at the ER surface

Biederer T, Volkwein C and Sommer T. Science. Dec 1997, 278:1806-9, doi: 10.1126/science.278.5344.1806. Read PDF »

Selected Reviews and Book Chapters

Synaptic recognition molecules in development and disease

Chowdhury, D., Watters, K. and Biederer, T. In: Current Topics in Developmental Biology (Academic Press). Editor: GJ Bashaw. Feb 2021, doi.org/10.1016/bs.ctdb.2020.12.009. Read PDF »

Adhesive brakes on plasticity: Emerging roles of synapse organizers in the regulation of critical periods

Ribic, A. and Biederer, T. Neural Plasticity. Sep 2019, doi: 10.1155/2019/1538137. Read PDF »

Trans-cellular nano-alignment of synaptic function

Biederer, T., Kaeser, P.S. and Blanpied, T.A. Neuron. Nov 2017, 96: 680-696. Read PDF »

Synaptic cell adhesion

Missler M, Südhof TC and Biederer T. In: Synapses. Editors: TC Südhof, M Sheng, B Sabatini. Cold Spring Harbor Laboratory Press. 2012, pp. 31-48. Read PDF »

Signaling by synaptogenic molecules

Biederer T and Stagi M. Current Opinion in Neurobiology. Jun 2008, 18:261-9, doi: 10.1016/j.conb.2008.07.014. Read PDF »

Cell-cell interactions in synaptogenesis

Akins MR and Biederer T. Current Opinion Neurobiology. Feb 2006, 16:83-9, doi: 10.1016/j.conb.2006.01.009. Read PDF »